6 Regardless of the starting or final dose amount, the neurological or clinical response should guide your therapy. No maximum daily dose has been determined in veterinary patients. 2 Despite the large dosing range ,0.25 ml/kg/min for 30-60 minutes is commonly used. Reported dose ranges in the literature include boluses of 1.5 ml/kg-2.0 ml/kg over 2-15 minutes, then as a CRI 0.06 ml/kg/min to 0.5 ml/kg/min for multiple hours. ![]() Aseptic technique should be used when administering ILE to prevent bacterial contamination and secondary sepsis in patients. Lipids are usually given IV in a peripheral catheter, but can be given in a central catheter as well to avoid potential phlebitis. 2 Regardless of its exact mechanism of action, physicians and veterinarians can document their experiences with ILE on the “Lipid Rescue” website ( ). The latter is most favored and supposes that ILE acts as a discrete department in the plasma which prevents the lipophilic compound from reaching its site of action. The exact mechanism of action of ILE is not known but there are two main theories: the metabolic theory and the “lipid sink” effect. ![]() 4 Additionally, there have been multiple review articles regarding lipid use in small animal poisoning. A recent article details the use of ILE in the treatment of severe diitiazem toxicosis in a dog along with high-dose insulin therapy. Reports of ILE use in veterinary medicine include use with overdoses of macrocyclic lactones, local anethestics, permethrin, baclofen, and some calcium channel blockers. Lipophilic compounds are those that combine with or dissolve with lipids. In animals, there are many case reports of its use in dogs 3,4,5 and cats 1,6,7 with various toxicities-specifically with lipophilic compounds. However, its use has been reported in humans as adjunct treatment for local anesthetic systemic toxicosis (LAST). Photo courtesy of There are no reported definitive uses of ILE in the human or veterinary literature. ![]() Veterinary Clinic for Low Income Pet Owners.Vet Services Report Cruelty Animal Advocacy Adopt
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